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Whole body hyperthermia by extracorporeal circulation in spontaneously breathing sarcoma patients: Hemodynamics and oxygen metabolism

Whole body hyperthermia by extracorporeal circulation in spontaneously breathing sarcoma patients: Hemodynamics and oxygen metabolism

Int J Artif Organs 2011; 34(11): 1085 - 1094

Article Type: ORIGINAL ARTICLE

DOI:10.5301/ijao.5000009

Authors

Gottfried J. Locker, Eva-Maria Fuchs, Nina Wore, Andja Bojic, Gerhard Heinrich, Thomas Brodowicz, Martin Clodi, Georg-Christian Funk, Paul Knöbl, Christoph C. Zielinski, Wolfgang J. Köstler

Abstract

Purpose: This phase I study was performed to evaluate the feasibility and toxicity of a new method of extracorporeal perfusion-induced whole body hyperthermia (WBHT) in patients with advanced sarcoma avoiding the need of intubation and general anesthesia.?Methods: One double-lumen femoral venous access was inserted by Seldinger´s technique to obtain WBHT (41.8°C for 120 minutes) via an extracorporeal circuit. No concomitant chemotherapy was applied. Up to 4 treatments of WBHT were performed under moderate sedation in 6 spontaneously breathing patients. Invasive hemodynamic monitoring was performed by use of a pulmonary artery catheter.?Results: After their first WBHT session, 2 patients were excluded from further treatment due to transient liver toxicity or catheter-related complication, so a total of 12 cycles remained for analyses. In all patients, conscious sedation resulted in sufficient spontaneous respiration without the need for mandatory ventilation. Median time to reach the target temperature was 84 minutes (range 60-142). Hemodynamic changes revealed the expected hyperdynamic state: heart rate, cardiac index, and stroke volume index significantly increased (p<0.05), whereas blood pressure and systemic and pulmonary vascular resistance index significantly decreased (p<0.05). A net fluid balance of 5822+1766 mL as well as norepinephrine (mean; 0.062 µg·kg1·min-1) were necessary to maintain the mean arterial blood pressure >60 mmHg.?Conclusion: Our data demonstrate the feasibility of this method of extracorporeal WBHT without mandatory ventilation. Hemodynamic side effects in spontaneously breathing patients during perfusion-induced WBHT seem less severe than those observed in radiant heat WBHT.

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Authors

  • Locker, Gottfried J. [PubMed] [Google Scholar]
    Intensive Care Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna - Austria and Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna - Austria and Center of Medical Intensive Care, Medical University of Vienna, Vienna - Austria and Early Clinical Development Program, Comprehensive Cancer Center, Medical University of Vienna, Vienna - Austria
  • Fuchs, Eva-Maria [PubMed] [Google Scholar]
    Intensive Care Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna - Austria
  • Wore, Nina [PubMed] [Google Scholar]
    Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna - Austria
  • Bojic, Andja [PubMed] [Google Scholar]
    Intensive Care Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna - Austria
  • Heinrich, Gerhard [PubMed] [Google Scholar]
    Intensive Care Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna - Austria
  • Brodowicz, Thomas [PubMed] [Google Scholar]
    Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna - Austria and Early Clinical Development Program, Comprehensive Cancer Center, Medical University of Vienna, Vienna - Austria
  • Clodi, Martin [PubMed] [Google Scholar]
    Divison of Endocrinology, Department of Internal Medicine III, Medical University of Vienna, Vienna - Austria
  • Funk, Georg-Christian [PubMed] [Google Scholar]
    Division of Pulmonology, Department of Internal Medicine II, Medical University of Vienna, Vienna - Austria
  • Knöbl, Paul [PubMed] [Google Scholar]
    Center of Medical Intensive Care, Medical University of Vienna, Vienna - Austria and Divison of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna - Austria
  • Zielinski, Christoph C. [PubMed] [Google Scholar]
    Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna - Austria and Early Clinical Development Program, Comprehensive Cancer Center, Medical University of Vienna, Vienna - Austria
  • Köstler, Wolfgang J. [PubMed] [Google Scholar]
    Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna - Austria and Early Clinical Development Program, Comprehensive Cancer Center, Medical University of Vienna, Vienna - Austria

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