Suicide and fratricide in bacterial biofilms


Bacterial autolysis has recently been identified as a key mechanism that regulates different  phases of biofilm development including microcolony formation and dispersal. However such autolytic measures are limited to a subfraction of cells within the entire biofilm population. Here we speculate on the role biofilm heterogeneity plays in limiting autolysis within biofilms and further describe the molecular regulation of suicidal and fratricidal mechanisms in biofilm development of Staphylococcus aureus and Enterococcus faecalis.

Int J Artif Organs 2009; 32(9): 537 - 544

Article Type: REVIEW


Vinai Chittezham Thomas, Lynn E. Hancock

Article History

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