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  • Editor in Chief: Prof. Andrea Remuzzi
  • Frequency: monthly
  • Current issue: Vol. 37 issue 10 , 2014 (October)

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Vol. 32 issue 9 (September 2009 - Focus on Implant Infections)

Suicide and fratricide in bacterial biofilms

Suicide and fratricide in bacterial biofilms

Int J Artif Organs 2009; 32(9): 537 - 544

Article Type: REVIEW

Authors

Vinai Chittezham Thomas, Lynn E. Hancock

Abstract

Bacterial autolysis has recently been identified as a key mechanism that regulates different  phases of biofilm development including microcolony formation and dispersal. However such autolytic measures are limited to a subfraction of cells within the entire biofilm population. Here we speculate on the role biofilm heterogeneity plays in limiting autolysis within biofilms and further describe the molecular regulation of suicidal and fratricidal mechanisms in biofilm development of Staphylococcus aureus and Enterococcus faecalis.

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