Predicting aortic growth in acute type B dissection is fundamental in planning interventions. Several factors are considered to be growth predictors in the literature and, among them, size and location of entry tears have been recognized to particularly influence the false lumen pressure. In this study, we develop an in vitro setting to analyze the actual impact of size and location of the entry tears on false lumen pressure, in the absence of other confounding factors such as the deformability of the aortic wall.
We formalize some indexes that synthetically describe the false lumen pressure with respect to the true lumen pressure. Then, we experimentally derive their values in several configurations of the in vitro setting, and we look for trends in the indexes with respect to the size and location of entry tears.
Results show that the tears have a relevant impact on the false lumen pressure, but that their size and location alone are not enough to explain the phenomena observed in vivo.
To predict the behavior of acute type B dissection, we therefore recommend not limiting to size and location, as many effects may derive from the interactions between these parameters and other patient characteristics.
Int J Artif Organs 2017; 40(10): 563 - 574
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsStefania Marconi, Ettore Lanzarone, Hector De Beaufort, Michele Conti, Santi Trimarchi, Ferdinando Auricchio
- • Accepted on 21/06/2017
- • Available online on 04/10/2017
- • Published in print on 13/10/2017
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- Marconi, Stefania [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
- Lanzarone, Ettore [PubMed] [Google Scholar] 2
- De Beaufort, Hector [PubMed] [Google Scholar] 3
- Conti, Michele [PubMed] [Google Scholar] 1
- Trimarchi, Santi [PubMed] [Google Scholar] 3
- Auricchio, Ferdinando [PubMed] [Google Scholar] 2
Department of Civil Engineering and Architecture, University of Pavia, Pavia - Italy
National Research Council of Italy - Institute for Applied Mathematics and Information Technologies (CNR-IMATI), Milan - Italy
IRCCS Policlinico San Donato, San Donato Milanese, Milan - Italy