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Report on 50 cases of severe acute hypotension at donor plasmaphereses: treatment and course

Report on 50 cases of severe acute hypotension at donor plasmaphereses: treatment and course

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Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/ijao.5000589

Authors

Josef Evers, George B. Schreiber, Uwe Taborski

Abstract

Introduction

This paper reports our experience in 50 cases with severe hypotensive reactions at plasma donations (synonymous with donor plasmaphereses).

Methods

Plasma donors who developed a severe acute hypotensive reaction at donor plasmapheresis, and were treated by placing the donor in the Trendelenburg position and rapid infusion of 1,000 mL saline were investigated. Plasmaphereses were performed with the Haemonetics® plasma collecting system 2 (PCS2). The results were analyzed using Excel.

Results

We observed 50 severe hypotensive reactions in plasma donors. The average systolic and diastolic blood pressures (SBP, DBP) were 128/75 mmHg – and heart rates were 78 beats/min (B/M) before plasmaphereses, 83/56 mmHg – 60 B/M at the event, and after treatment 119/71 mmHg – 69 B/M at the time of discharge. The volume of collected plasma was 602 ± 240 mL including anticoagulant (AC). The time until the event was 45 ± 20 minutes. With treatment 49 ± 18 minutes after the event all plasma donors had normal blood pressures and heart rates and could safely leave the center.

Conclusions

Treatment by placing the donor in the Trendelenburg position and rapid infusion of 1,000 mL saline appears to be an effective procedure for resolving severe acute hypotension associated with donor plasmaphereses.

Article History

Disclosures

Financial support: No grants or funding have been received for this study.
Conflict of interest: None of the authors has financial interest related to this study to disclose. The views expressed here are those of the authors and not the official position of Octapharma Plasma, Langenfeld, Germany, or PPTA, Annapolis, USA.
Meeting presentation: Section Meeting for Preparative and Therapeutic Plasmapheresis at the Joint Congress DGTI & DGI held in Nuremberg, September 7, 2016.

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Authors

Affiliations

  • Octapharma Plasma, Plasmazentrum Aachen, Aachen - Germany
  • Plasma Protein Therapeutics Association (PPTA), Annapolis - USA

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