Tissue advanced glycation end products (AGE) are increased in hemodialysis (HD) patients, especially those with cardiovascular complications. Skin autofluorescence (skin-AF) can noninvasively estimate the accumulation of AGE in tissue. The aim was to clarify whether HD using a high-flux (HF) dialyzer favors plasma- or skin-AF removal compared to low-flux (LF) dialysis.
28 patients were treated with either an HF-HD or LF-HD but otherwise unchanged conditions in a cross-over design. A glucose containing dialysate was used. Skin-AF was measured noninvasively with an AGE reader before and after HD. Fluorescence (370 nm/465 nm) of plasma (p-AF) was determined as total and nonprotein-bound fractions. Correction for hemoconcentrations were made using the change in serum albumin. Paired and nonpaired statistical analyses were used.
Skin-AF was unchanged after LF- and HF-dialysis. Total, free, and protein- bound p-AF was reduced after a single LF-HD by 21%, 28%, and 17%, respectively (
In the dialysis settings used there was no significant change in skin AF after dialysis, with LF or with HF dialysis. Although only limited reduction in plasma fluorescence was observed, this was more pronounced when performing LF dialysis. These data are not in overwhelming support of the use of HF dialysis in the setting used in this study.
Int J Artif Organs 2015; 38(9): 488 - 493
Article Type: ORIGINAL RESEARCH ARTICLE
Article Subject: Artificial kidney, apheresis and detoxification techniques
AuthorsBernd Ramsauer, Gerwin Engels, Stefan Arsov, Henrik Hadimeri, Aleksandar Sikole, Reindert Graaff, Bernd Stegmayr
- • Accepted on 14/09/2015
- • Available online on 09/10/2015
- • Published in print on 19/10/2015
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- Ramsauer, Bernd [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Engels, Gerwin [PubMed] [Google Scholar] 2
- Arsov, Stefan [PubMed] [Google Scholar] 3
- Hadimeri, Henrik [PubMed] [Google Scholar] 1
- Sikole, Aleksandar [PubMed] [Google Scholar] 4
- Graaff, Reindert [PubMed] [Google Scholar] 5
- Stegmayr, Bernd [PubMed] [Google Scholar] 1
Department of Public Health and Clinical Medicine, Umea University, Umea - Sweden
HaemoScan B.V., Groningen - The Netherlands
Institute of Epidemiology and Biostatistics with Medical Informatics Medical Faculty, Skopje - Macedonia
Hospital of Nephrology, Ss. Cyril and Methodius University, Skopje - Macedonia
UMC Staff and Department of Endocrinology, University Medical Center Groningen and University of Groningen, Groningen - The Netherlands