Buccal mucosa repair with electrospun silk fibroin matrix in a rat model
Post author correction
Article Type: ORIGINAL ARTICLE
Article Subject: Tissue engineering, regenerative medicine and tissue transplantation
DOI:10.5301/ijao.5000392
Authors
Jing Tang, Yongjie Han, Feng Zhang, Zili Ge, Xi Liu, Qiang Lu
Corresponding author
- Zili Ge
- Department of Stomatology
- 188 Shizi Street
- Suzhou 215006, China
- [email protected]
Abstract
Biomimic electrospun matrix derived from silk fibroin nanofiber solution was recently prepared in our group. The feasibility of the matrix as mucosa repair scaffold was evaluated in a rat model in the present study.
Full thickness wound was established on the buccal mucosa of male Wister rats via microscopic oral surgery. 80 rats were randomly assigned into 4 groups: (1) silk fibroin matrix, (2) commercial cowhide acellular dermal matrix (Heal-All), (3) commercial acellular dermal matrix of human skin (RENOV), and (4) vaseline gauze, respectively.
The silk fibroin matrix showed similar repair performance compared to the commercial acellular dermal matrices, implying promising applications in mucosa regeneration. More importantly, the silk fibroin matrix showed better wound healing ability, improved wound shrinkage inhibition, and reduced local immunological incompatibility.
The silk fibroin scaffold performed satisfied in scar tissue inhibition and epidermis regeneration. Taking into account its improved mechanical properties, the biomimic electrospun silk matrix could become a promising substitute of acellular dermal matrix in clinical applications.
Article History
- • Accepted on 18/01/2015
- • Available online on 04/03/2015
Disclosures
This article is available as full text PDF.
Authors
- Tang, Jing [PubMed] [Google Scholar] 1
- Han, Yongjie [PubMed] [Google Scholar] 2
- Zhang, Feng [PubMed] [Google Scholar] 3
- Ge, Zili [PubMed] [Google Scholar] 1, * Corresponding Author ([email protected])
- Liu, Xi [PubMed] [Google Scholar] 4
- Lu, Qiang [PubMed] [Google Scholar] 3, 4
Affiliations
-
Department of Stomatology, The First Affiliated Hospital of Soochow University, Suzhou - China -
Department of Maxillofacial Surgery Qinghai Province People’s Hospital, Xining - China -
Jiangsu Province Key Laboratory of Stem Cell Research, Medical College, Soochow University, Suzhou - China -
National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou - China -
Jing Tang and Yongjie Han contributed equally
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