Biomimetic principles to develop blood compatible surfaces
Int J Artif Organs 2017; 40(1): 22 - 30
Article Type: REVIEW
AuthorsVladislav Semak, Michael B. Fischer, Viktoria Weber
Functionalized biomaterial surface patterns capable of resisting nonspecific adsorption while retaining their bioactivity are crucial in the advancement of biomedical technologies, but currently available biomaterials intended for use in whole blood frequently suffer from nonspecific adsorption of proteins and cells, leading to a loss of activity over time. In this review, we address two concepts for the design and modification of blood compatible biomaterial surfaces, zwitterionic modification and surface functionalization with glycans – both of which are inspired by the membrane structure of mammalian cells – and discuss their potential for biomedical applications.
- • Accepted on 27/01/2017
- • Available online on 13/02/2017
- • Published in print on 06/03/2017
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- Semak, Vladislav [PubMed] [Google Scholar] 1
- Fischer, Michael B. [PubMed] [Google Scholar] 2
- Weber, Viktoria [PubMed] [Google Scholar] 1, 2, * Corresponding Author (firstname.lastname@example.org)
Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis, Danube University Krems, Krems - Austria
Department for Health Sciences and Biomedicine, Danube University Krems, Krems - Austria