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Biomimetic principles to develop blood compatible surfaces

Biomimetic principles to develop blood compatible surfaces

Int J Artif Organs 2017; 40(1): 22 - 30

Article Type: REVIEW

DOI:10.5301/ijao.5000559

Authors

Vladislav Semak, Michael B. Fischer, Viktoria Weber

Abstract

Functionalized biomaterial surface patterns capable of resisting nonspecific adsorption while retaining their bioactivity are crucial in the advancement of biomedical technologies, but currently available biomaterials intended for use in whole blood frequently suffer from nonspecific adsorption of proteins and cells, leading to a loss of activity over time. In this review, we address two concepts for the design and modification of blood compatible biomaterial surfaces, zwitterionic modification and surface functionalization with glycans – both of which are inspired by the membrane structure of mammalian cells – and discuss their potential for biomedical applications.

Article History

Disclosures

Financial support: The authors gratefully acknowledge the Christian Doppler Society for financial support within the Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis project and the OeAD for Ernst Mach Grant to V.S..
Conflict of interest: None of the authors has financial interest related to this study to disclose.

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Authors

Affiliations

  •  Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis, Danube University Krems, Krems - Austria
  •  Department for Health Sciences and Biomedicine, Danube University Krems, Krems - Austria

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