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Mechanisms of endothelial activation in sepsis and cell culture models to study the heterogeneous host response

Mechanisms of endothelial activation in sepsis and cell culture models to study the heterogeneous host response

Int J Artif Organs 2017; 40(1): 9 - 14

Article Type: REVIEW

DOI:10.5301/ijao.5000560

Authors

Tanja Eichhorn, Michael B. Fischer, Viktoria Weber

Abstract

Sepsis is currently viewed as a fundamental disintegration of control functions from intracellular signalling to immunoregulatory and neuroendocrine mechanisms. The immediate threat in sepsis is invasive infection, and the need to activate immune defense mechanisms to clear the pathogen before irreparable damage occurs. In the process of pathogen elimination, however, the systemic host response to infection may cause collateral damage to the endothelium and may lead to the destruction of host tissues.

A number of experimental models have been developed to monitor endothelial activation and to study endothelial dysfunction under septic conditions. Here, we review the application of these models to assess the highly variable host response in sepsis and to investigate the efficacy of adsorbent-based extracorporeal therapies. We also highlight the need for efficient diagnostic tools, which are indispensable to select patients who are likely to benefit from distinct adjunctive therapies.

Article History

Disclosures

Financial support: This work was funded by the Christian Doppler Society within the Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis.
Conflict of interest: None of the authors has financial interest related to this study to disclose.

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Authors

Affiliations

  • Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis, Department for Health Sciences and Biomedicine, Danube University Krems, Krems - Austria

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