Abstract
To improve the stability of pectin-oligochitosan hydrogel microcapsules under physiological conditions.
Two different approaches were examined: change of the cross-linker length and treatment of the hydrogel microcapsules with 150 Mm CaCl2. Replacement of pectin with alginate was also studied.
It was observed that the molecular weight of the cross-linker oligochiotsan had no significant improvement on microcapsule stability. On the other hand, the treatment of pectin-oligochitosan microcapsules with Ca2+ increased the microcapsule stability significantly. Different types of alginate were used; however, no red-blood-cell-shaped microcapsules could be produced, which is likely due to the charge-density difference between deprotonated pectin and alginate polymers.
Int J Artif Organs 2016; 39(10): 518 - 523
Article Type: ORIGINAL RESEARCH ARTICLE
DOI:10.5301/ijao.5000532
Authors
Wujie Zhang, Matthew J. Bissen, Emily S. Savela, Joshua N. Clausen, Samantha J. Fredricks, Xiaoru Guo, Zachary R. Paquin, Ryan P. Dohn, Ian J. Pavelich, Alec L. Polovchak, Michael J. Wedemeyer, Brock E. Shilling, Emily N. Dufner, Anna C. O’Donnell, Gerardo Rubio, Logan R. Readnour, Tyler F. Brown, Jung C. Lee, Matey G. Kaltchev, Junhong Chen, Charles S. TrittArticle History
- • Accepted on 02/11/2016
- • Available online on 16/11/2016
- • Published in print on 29/11/2016
Disclosures
This article is available as full text PDF.
Authors
- Zhang, Wujie [PubMed] [Google Scholar] 1, * Corresponding Author ([email protected])
- Bissen, Matthew J. [PubMed] [Google Scholar] 1
- Savela, Emily S. [PubMed] [Google Scholar] 1
- Clausen, Joshua N. [PubMed] [Google Scholar] 1
- Fredricks, Samantha J. [PubMed] [Google Scholar] 1
- Guo, Xiaoru [PubMed] [Google Scholar] 2
- Paquin, Zachary R. [PubMed] [Google Scholar] 1
- Dohn, Ryan P. [PubMed] [Google Scholar] 1
- Pavelich, Ian J. [PubMed] [Google Scholar] 1
- Polovchak, Alec L. [PubMed] [Google Scholar] 1
- Wedemeyer, Michael J. [PubMed] [Google Scholar]
- Shilling, Brock E. [PubMed] [Google Scholar] 1
- Dufner, Emily N. [PubMed] [Google Scholar] 1
- O’Donnell, Anna C. [PubMed] [Google Scholar] 1
- Rubio, Gerardo [PubMed] [Google Scholar] 1
- Readnour, Logan R. [PubMed] [Google Scholar]
- Brown, Tyler F. [PubMed] [Google Scholar] 1
- Lee, Jung C. [PubMed] [Google Scholar] 1
- Kaltchev, Matey G. [PubMed] [Google Scholar] 1
- Chen, Junhong [PubMed] [Google Scholar] 2, * Corresponding Author ([email protected])
- Tritt, Charles S. [PubMed] [Google Scholar] 3
Affiliations
-
BioMolecular Engineering Program, Department of Physics and Chemistry, Milwaukee School of Engineering, Milwaukee, WI - USA -
Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI - USA -
Biomedical Engineering Program, Department of Electrical Engineering and Computer Science, Milwaukee School of Engineering, Milwaukee, WI - USA
Article usage statistics
The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.