The Vietnamese pig as a translational animal model to evaluate tissue engineered heart valves: promising early experience
Int J Artif Organs 2017; 40(4): 142 - 149
Article Type: REVIEW
DOI:10.5301/ijao.5000568
Authors
Michele Gallo, Helen Poser, Tommaso Bottio, Antonella Bonetti, Paolo Franci, Filippo Naso, Edward Buratto, Fabio Zanella, Giovanni Perona, Carlo Dal Lin, Roberto Bianco, Michele Spina, Roberto Busetto, Maurizio Marchini, Fulvia Ortolani, Laura Iop, Gino GerosaAbstract
Several animal models are currently used for the surgical implantation of either biologic or biopolymeric scaffolds in order to provide in vivo assessment of tissue-engineered heart valves. The Vietnamese pig (VP) is herein proposed as a suitable recipient to test the function of novel bioengineered valve substitutes, in the reconstruction of the right ventricular outflow tract (RVOT). This review aims to provide a complete and exhaustive panel of physiological parameters and methodological information for preclinical studies of tissue-engineered heart valves in the VP animal model.
Article History
- • Accepted on 10/02/2017
- • Available online on 27/03/2017
- • Published in print on 09/05/2017
Disclosures
This article is available as full text PDF.
Authors
- Gallo, Michele [PubMed] [Google Scholar] 1
- Poser, Helen [PubMed] [Google Scholar] 2
- Bottio, Tommaso [PubMed] [Google Scholar] 1
- Bonetti, Antonella [PubMed] [Google Scholar] 3
- Franci, Paolo [PubMed] [Google Scholar] 2
- Naso, Filippo [PubMed] [Google Scholar] 1
- Buratto, Edward [PubMed] [Google Scholar] 4
- Zanella, Fabio [PubMed] [Google Scholar] 1
- Perona, Giovanni [PubMed] [Google Scholar] 5
- Dal Lin, Carlo [PubMed] [Google Scholar] 1
- Bianco, Roberto [PubMed] [Google Scholar] 1
- Spina, Michele [PubMed] [Google Scholar] 2
- Busetto, Roberto [PubMed] [Google Scholar] 2
- Marchini, Maurizio [PubMed] [Google Scholar] 3
- Ortolani, Fulvia [PubMed] [Google Scholar] 3
- Iop, Laura [PubMed] [Google Scholar] 1, 6
- Gerosa, Gino [PubMed] [Google Scholar] 1, 6, * Corresponding Author (gino.gerosa@unipd.it)
Affiliations
-
Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua - Italy -
Department of Animal Medicine, Production and Health, University of Padua, Padua - Italy -
Department of Experimental and Clinical Medicine, University of Udine, Udine - Italy -
Department of Cardiothoracic Surgery, Royal Children’s Hospital, Murdoch Children’s Research Institute, University of Melbourne, Melbourne - Australia -
CISRA Institute, University of Turin, Turin - Italy -
Cardiovascular Regenerative Medicine, Venetian Institute of Molecular Medicine (VIMM), Biomedical Campus Pietro d’Abano, Padua - Italy
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