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The Vietnamese pig as a translational animal model to evaluate tissue engineered heart valves: promising early experience

The Vietnamese pig as a translational animal model to evaluate tissue engineered heart valves: promising early experience

Int J Artif Organs 2017; 40(4): 142 - 149

Article Type: REVIEW

DOI:10.5301/ijao.5000568

Authors

Michele Gallo, Helen Poser, Tommaso Bottio, Antonella Bonetti, Paolo Franci, Filippo Naso, Edward Buratto, Fabio Zanella, Giovanni Perona, Carlo Dal Lin, Roberto Bianco, Michele Spina, Roberto Busetto, Maurizio Marchini, Fulvia Ortolani, Laura Iop, Gino Gerosa

Abstract

Several animal models are currently used for the surgical implantation of either biologic or biopolymeric scaffolds in order to provide in vivo assessment of tissue-engineered heart valves. The Vietnamese pig (VP) is herein proposed as a suitable recipient to test the function of novel bioengineered valve substitutes, in the reconstruction of the right ventricular outflow tract (RVOT). This review aims to provide a complete and exhaustive panel of physiological parameters and methodological information for preclinical studies of tissue-engineered heart valves in the VP animal model.

Article History

Disclosures

Financial support: This research was supported by grants (Azione Biotech III and RSF 286/08) from the Health Department of the Veneto Region, Italy.
Conflict of interest: None of the authors has financial interest related to this study to disclose.

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Authors

Affiliations

  • Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua - Italy
  • Department of Animal Medicine, Production and Health, University of Padua, Padua - Italy
  • Department of Experimental and Clinical Medicine, University of Udine, Udine - Italy
  • Department of Cardiothoracic Surgery, Royal Children’s Hospital, Murdoch Children’s Research Institute, University of Melbourne, Melbourne - Australia
  • CISRA Institute, University of Turin, Turin - Italy
  • Cardiovascular Regenerative Medicine, Venetian Institute of Molecular Medicine (VIMM), Biomedical Campus Pietro d’Abano, Padua - Italy

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