High cut-off membranes in acute kidney injury and continuous renal replacement therapy


Innovation in continuous renal replacement therapies (CRRT) utilized to treat acute kidney injury (AKI) and sepsis, has brought new machines and techniques. Part of these new advances are due to the availability of innovative biomaterials and the construction of membranes with larger pores and wide distribution of pore sizes. This includes the creation of a new generation of high cut-off membranes whose utilization in clinical practice is promising for the wide spectrum of solutes that are removed during extracorporeal therapies.

However, the enlargement of pore diameters brings some loss of albumin during treatment and this effect is still under evaluation, since there is a possibility that this is detrimental for the patient. A thorough review of the available clinical literature is reported in this paper with a reappraisal of the potential application of these new technologies.

Int J Artif Organs 2017; 40(12): 657 - 664

Article Type: REVIEW



Zaccaria Ricci, Stefano Romagnoli, Claudio Ronco

Article History


Financial support: None.
Conflict of interest: None.

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  • Department of Cardiology and Cardiac Surgery, Pediatric Cardiac Intensive Care Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome - Italy
  • Department of Anesthesiology and Intensive Care, Careggi University Hospital, Florence - Italy
  • Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza - Italy
  • International Renal Research Institute of Vicenza (IRRIV), Vicenza - Italy

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