To develop and test a lumped parameter model to simulate and compare the effects of the simultaneous use of continuous flow (CF) and pulsatile flow (PF) ventricular assist devices (VADs) to assist biventricular circulation vs. single ventricle circulation in pediatrics.
Baseline data of 5 patients with biventricular circulation eligible for LVAD and of 5 patients with Fontan physiology were retrospectively collected and used to simulate patient baselines. Then, for each patient the following simulations were performed: (a) CF VAD to assist the left ventricle (single ventricle) + a PF VAD to assist the right ventricle (cavo-pulmonary connection) (LCF + RPF); (b) PF VAD to assist the left ventricle (single ventricle) + a CF VAD to assist the right ventricle (cavo-pulmonary connection) (RCF + LPF)
In biventricular circulation, the following results were found: cardiac output (17% RCF + LPF, 21% LCF + RPF), artero-ventricular coupling (-36% for the left ventricle and -21.6% for the right ventricle), pulsatility index (+6.4% RCF + LPF, p = 0.02; -8.5% LCF + RPF, p = 0.00009). Right (left) atrial pressure and right (left) ventricular volumes are decreased by the RCF + LPF (by RPF + LCF). Pulmonary arterial pressure decreases in the LCF + RPF configuration. In Fontan physiology: cardiac output (LCF + RPF 35% vs. 8% in RCF + LPF), ventricular preload (+4% RCF + LPF, -10% LCF + RPF), Fontan conduit pressure (-5% RCF + LPF, +7% LCF + RPF), artero-ventricular coupling (-14% RCF + LPF vs. -41% LCF + RPF) and pulsatility (+13% RCF + LPF, - 8% LCF + RPF).
A numerical model supports clinicians in defining and innovating the VAD implantation strategy to maximize the hemodynamic benefits. Results suggest that the hemodynamic benefits are maximized by the LCF + RPF configuration.
Int J Artif Organs 2017; 40(2): 74 - 81
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsArianna Di Molfetta, Gianfranco Ferrari, Roberta Iacobelli, Sergio Filippelli, Paolo Guccione, Libera Fresiello, Gianluigi Perri, Antonio Amodeo
- • Accepted on 30/01/2017
- • Available online on 11/02/2017
- • Published in print on 16/03/2017
This article is available as full text PDF.
- Di Molfetta, Arianna [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
- Ferrari, Gianfranco [PubMed] [Google Scholar] 2
- Iacobelli, Roberta [PubMed] [Google Scholar] 1
- Filippelli, Sergio [PubMed] [Google Scholar] 1
- Guccione, Paolo [PubMed] [Google Scholar] 1
- Fresiello, Libera [PubMed] [Google Scholar] 3
- Perri, Gianluigi [PubMed] [Google Scholar] 1
- Amodeo, Antonio [PubMed] [Google Scholar] 1
Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Pediatric Hospital, Rome - Italy
Institute of Clinical Physiology, National Research Center, Rome - Italy
Department of Cardiac Surgery, Catholic University of Leuven, Leuven - Belgium