Sedentariness, high inflammation status and malnutrition are highly prevalent in end-stage kidney disease patients on maintenance hemodialysis (MHD). This study investigated associations of weekly physical activity energy expenditure (PAEE) with clinical and anthropometric markers of nutrition and inflammation.
The analysis was performed using baseline cross-sectional data of 640 patients enrolled in the prospective cohort “The Prospective Study of the Prognosis of Patients Treated Chronically by Hemodialysis” (PROHEMO) developed in Salvador, BA, Brazil. The long version of the International Physical Activity Questionnaire was used to determine a summary measure of PAEE, the metabolic equivalent of task (MET), taking into account physical activities related to occupation, recreation, travel, sports, and housework. PAEE was the predictor variable. To assess associations of PAEE with outcomes, the sex-age-specific median MET was used. The malnutrition-inflammation score (MIS) with range of 0 to 30 (higher is worse), conicity index as indicator of abdominal adiposity and C-reactive protein (CRP) were the nutritional-inflammatory outcomes.
The mean age of the patients was 48.9 ± 13.8 y, 60.3% were males, 16.7% diabetic, 88.1% nonwhite. In multivariable logistic regression models with adjustments for sociodemographic variables and comorbidities, PAEE ≤median was associated with MIS ≥6 (odds ratio [OR] = 1.57; 95% confidence interval [CI] = 1.08, 2.29), conicity index ≥1.3 (OR = 1.52, 95% CI = 1.03, 2.23) and CRP >1.30 mg/dL (OR = 1.69, 95% CI = 1.08, 2.84).
Greater physical activity assessed by PAEE was associated with indicators of better nutritional and inflammation status. These results indicate opportunities for improving outcomes in MHD patients by counseling and treatment intervention.
Int J Artif Organs 2017; 40(12): 670 - 675
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsClarcson P. Santos, Luciana F. Silva, Marcelo B. Lopes, Márcia T.S. Martins, Angiolina C. Kraychete, Fernanda A. Silva, Maria T.S. Martins, Cácia M. Matos, Gildete B. Lopes, Antonio A. Lopes
- • Accepted on 22/06/2017
- • Available online on 11/08/2017
- • Published in print on 24/11/2017
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- Santos, Clarcson P. [PubMed] [Google Scholar] 1
- Silva, Luciana F. [PubMed] [Google Scholar] 2
- Lopes, Marcelo B. [PubMed] [Google Scholar] 1
- Martins, Márcia T.S. [PubMed] [Google Scholar] 1, 3
- Kraychete, Angiolina C. [PubMed] [Google Scholar] 1, 4
- Silva, Fernanda A. [PubMed] [Google Scholar] 1, 5
- Martins, Maria T.S. [PubMed] [Google Scholar] 1
- Matos, Cácia M. [PubMed] [Google Scholar] 1, 4
- Lopes, Gildete B. [PubMed] [Google Scholar] 1, 6
- Lopes, Antonio A. [PubMed] [Google Scholar] 6, 7, * Corresponding Author (firstname.lastname@example.org)
Graduate Program in Medicine and Health, Federal University of Bahia, Salvador, BA - Brazil
Department of Life Sciences, Bahia State University, Salvador, BA - Brazil
Clínica do Rim e Hipertensão Arterial (CLINIRIM), Salvador, BA - Brazil
Instituto de Nefrologia e Diálise (INED), Salvador, BA - Brazil
NEPHRON Clinic, Salvador, BA - Brazil
Unit of Clinical Epidemiology and Evidence Based Medicine, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA - Brazil
Department of Internal Medicine, Federal University of Bahia, Salvador, BA - Brazil