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Associations of physical activity energy expenditure with nutritional-inflammatory markers in hemodialysis patients

Abstract

Background

Sedentariness, high inflammation status and malnutrition are highly prevalent in end-stage kidney disease patients on maintenance hemodialysis (MHD). This study investigated associations of weekly physical activity energy expenditure (PAEE) with clinical and anthropometric markers of nutrition and inflammation.

Methods

The analysis was performed using baseline cross-sectional data of 640 patients enrolled in the prospective cohort “The Prospective Study of the Prognosis of Patients Treated Chronically by Hemodialysis” (PROHEMO) developed in Salvador, BA, Brazil. The long version of the International Physical Activity Questionnaire was used to determine a summary measure of PAEE, the metabolic equivalent of task (MET), taking into account physical activities related to occupation, recreation, travel, sports, and housework. PAEE was the predictor variable. To assess associations of PAEE with outcomes, the sex-age-specific median MET was used. The malnutrition-inflammation score (MIS) with range of 0 to 30 (higher is worse), conicity index as indicator of abdominal adiposity and C-reactive protein (CRP) were the nutritional-inflammatory outcomes.

Results

The mean age of the patients was 48.9 ± 13.8 y, 60.3% were males, 16.7% diabetic, 88.1% nonwhite. In multivariable logistic regression models with adjustments for sociodemographic variables and comorbidities, PAEE ≤median was associated with MIS ≥6 (odds ratio [OR] = 1.57; 95% confidence interval [CI] = 1.08, 2.29), conicity index ≥1.3 (OR = 1.52, 95% CI = 1.03, 2.23) and CRP >1.30 mg/dL (OR = 1.69, 95% CI = 1.08, 2.84).

Conclusions

Greater physical activity assessed by PAEE was associated with indicators of better nutritional and inflammation status. These results indicate opportunities for improving outcomes in MHD patients by counseling and treatment intervention.

Int J Artif Organs 2017; 40(12): 670 - 675

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/ijao.5000632

Authors

Clarcson P. Santos, Luciana F. Silva, Marcelo B. Lopes, Márcia T.S. Martins, Angiolina C. Kraychete, Fernanda A. Silva, Maria T.S. Martins, Cácia M. Matos, Gildete B. Lopes, Antonio A. Lopes

Article History

Disclosures

Financial support: The study was supported by research grants from The Brazilian National Council for Scientific and Technological Development (CNPq), grants #309468/2009-4 and #480292/2009-4.
Conflict of interest: None of the authors has financial interest related to this study to disclose.

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Authors

Affiliations

  •  Graduate Program in Medicine and Health, Federal University of Bahia, Salvador, BA - Brazil
  •  Department of Life Sciences, Bahia State University, Salvador, BA - Brazil
  •  Clínica do Rim e Hipertensão Arterial (CLINIRIM), Salvador, BA - Brazil
  •  Instituto de Nefrologia e Diálise (INED), Salvador, BA - Brazil
  •  NEPHRON Clinic, Salvador, BA - Brazil
  •  Unit of Clinical Epidemiology and Evidence Based Medicine, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA - Brazil
  •  Department of Internal Medicine, Federal University of Bahia, Salvador, BA - Brazil

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