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Design and numerical evaluation of an axial partial-assist blood pump for Chinese and other heart failure patients

Abstract

A fully implantable axial left ventricular assist device LAP31 was developed for Chinese or other heart failure patients who need partial support. Based on the 5-Lpm total cardiac blood output of Chinese without heart failure disease, the design point of LAP31 was set to a flow rate of 3 Lpm with 100-mmHg pressure head. To achieve the required pressure head and good hemolytic performance, a structure that includes a spindly rotor hub and a diffuser with splitter and cantilevered main blades was developed. Computational fluid dynamics (CFD) was used to analyze the hydraulic and hemodynamic performance of LAP31. Then in vitro hydraulics experiments were conducted. The numerical simulation results show that LAP31 could generate a 1 to 8 Lpm flow rate with a 60.9 to 182.7 mmHg pressure head when the pump was rotating between 9,000 and 12,000 rpm. The average scalar shear stress of the blood pump was 21.7 Pa, and the average exposure time was 71.0 milliseconds. The mean hemolysis index of LAP31 obtained using Heuser’s hemolysis model and Giersiepen’s model was 0.220% and 3.89 × 10-5% respectively. After adding the splitter blades, the flow separation at the suction surface of the diffuser was reduced. The cantilever structure reduced the tangential velocity from 6.1 to 4.7-1.4 m/s within the blade gap by changing the blade gap from shroud to hub. Subsequently, the blood damage caused by shear stress was reduced. In conclusion, the hydraulic and hemolytic characteristics of the LAP31 are acceptable for partial support.

Int J Artif Organs 2017; 40(9): 489 - 497

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/ijao.5000616

Authors

Guang-Mao Liu, Dong-Hai Jin, Jian-Ye Zhou, Xi-Hang Jiang, Han-Song Sun, Yan Zhang, Hai-Bo Chen, Sheng-Shou Hu, Xing-Min Gui

Article History

Disclosures

Financial support: This research was supported by grants from the National Natural Science Foundation of China: (81550050) and (51236001) and Beijing Natural Science Foundation (No. 3151002).
Conflict of interest: None of the authors has financial interest related to this study to disclose.

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Authors

Affiliations

  • State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing - China
  • School of Energy and Power Engineering, Beihang University, Beijing - China
  • Co-Innovation Center for Advanced Aero-Engine, Beijing - China
  • Beijing Power Machinery Research Institute, Beijing - China

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